Anti-PSIP1 Antibody

Raised in rabbit against the chromatin-associated transcriptional coactivator PSIP1 (also known as LEDGF, p75, p52, DFS70, PAIP, and PSIP2), this polyclonal IgG reagent from Antibodies.com is supplied unconjugated as a 200 µl liquid for western blot detection in human, mouse, and rat samples.

PSIP1/LEDGF acts as a chromatin-tethering transcriptional coactivator that engages RNA polymerase II and has been linked to mRNA splicing and HIV-1 integration cofactor activity, making it a target of interest for studies of host-factor biology, lentiviral integration, and stress-response transcription in cell lysates and nuclear extracts.

For handling, the antibody should be aliquoted upon arrival and stored at -20°C, with repeated freeze-thaw cycles avoided to preserve activity. The unconjugated format gives users the flexibility to pair the rabbit IgG with a chosen labeled secondary antibody for chemiluminescent or fluorescent immunoblot detection.