Anti-PSD-95 Antibody

Antibodies.com supplies this recombinant rabbit monoclonal antibody directed against postsynaptic density protein 95 (PSD-95), a MAGUK-family scaffolding molecule that clusters NMDA and AMPA receptor subunits at excitatory glutamatergic synapses. Investigators deploy it to map receptor anchoring, track activity-dependent remodeling of the postsynaptic density, and probe molecular correlates of LTP and LTD in cultured neurons, acute brain slices, and in vivo tissue.

The reagent is validated for western blot analysis of synaptic membrane fractions, immunocytochemistry and immunofluorescence on dissociated hippocampal cultures or iPSC-derived neurons, immunohistochemistry on rodent and human brain sections, and flow cytometry-based expression profiling. Reactivity with human, mouse, and rat PSD-95 supports consistent antibody use from rodent disease models through patient-derived cell lines and human post-mortem samples.

Provided as 100 µl of recombinant rabbit monoclonal antibody in TBS pH 7.4 with 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative. The unconjugated format integrates cleanly with secondary antibodies of choice for chromogenic or fluorescence detection. Brief centrifugation before aliquoting preserves activity, and repeated freeze-thaw cycles should be avoided.