Anti-PSCA Antibody

This rabbit polyclonal antibody targets Prostate Stem Cell Antigen (PSCA), a GPI-anchored cell surface glycoprotein of the LY-6/Thy-1 family that is overexpressed in prostate adenocarcinoma and bladder transitional cell carcinoma and has been investigated as a tumor-associated antigen in pancreatic and renal cancers. Supplied by Antibodies.com as a 100 µl unconjugated reagent, it is validated for Western blot and ELISA workflows and reacts with both human and mouse PSCA, enabling translational studies that bridge murine disease models with clinical samples.

The polyclonal format recognises multiple epitopes across the PSCA extracellular domain, which is useful when working with denatured lysates or when broad recognition matters more than a single-epitope readout. For Western blot, the antibody can be paired with a species-matched anti-rabbit IgG-HRP secondary and standard chemiluminescent detection. The unconjugated presentation leaves the choice of label — biotin, HRP, fluorophore, or reporter tags — to the end user, so the same vial can serve both immunoblotting and plate-based immunoassays.

Recommended storage is at -20 °C in working aliquots to limit freeze-thaw cycles; short-term refrigerated handling is acceptable for active aliquots. Brief centrifugation before opening recovers full volume from the vial. Researchers studying prostate cancer biomarkers, bladder cancer diagnostics, or stem cell markers in epithelial tissues will find this reagent a practical starting point for characterising PSCA expression.