Anti-PRODH Antibody

Rabbit polyclonal antibody raised against human proline dehydrogenase 1 (PRODH), the mitochondrial flavoenzyme that catalyzes the first committed step of proline catabolism by oxidizing L-proline to Δ¹-pyrroline-5-carboxylate. This unconjugated primary reagent from Antibodies.com is supplied as 100 µl of antiserum and is validated for western blot and immunohistochemistry workflows on human samples.

PRODH maps to the 22q11.2 region, a locus associated with velo-cardio-facial syndrome and with schizophrenia susceptibility, and loss-of-function variants in the gene cause type I hyperprolinemia. Investigators working on amino acid metabolism, mitochondrial redox balance, and neurodevelopmental disorders therefore depend on specific recognition of the endogenous protein in cell lysates and in fixed tissue sections.

The host species is rabbit, the clonality is polyclonal, and the conjugate is unconjugated, leaving users free to couple the reagent to a preferred reporter or to adapt it for in-house detection assays. Aliquot upon arrival, store refrigerated between 2 and 8 degrees C, protect from light, and limit freeze-thaw cycles to preserve activity. For research use only.