Anti-PROC Antibody

Raised in rabbit against human Protein C, this polyclonal antibody from Antibodies.com is supplied as an unconjugated reagent in 100 µl volumes, intended for western blot and immunohistochemistry workflows. Protein C (PROC) is a vitamin K-dependent serine protease central to the anticoagulant pathway, where activated Protein C inactivates factors Va and VIIIa to modulate thrombin generation and downstream inflammatory signaling. Researchers investigating thrombophilia, venous thromboembolism, sepsis-associated coagulopathy, and inherited Protein C deficiency rely on anti-PROC reagents to profile expression in hepatic and endothelial tissues, the principal sites of PROC biosynthesis. On western blots, the antibody recognizes the full-length PROC zymogen, and IHC staining highlights cytoplasmic localization in hepatocytes and sinusoidal endothelium of human tissue sections. The polyclonal format binds multiple epitopes on the target, supporting consistent signal across denatured lysates and fixed preparations. Each lot is validated on relevant human samples to confirm specificity for the PROC antigen with negligible cross-reactivity toward homologous vitamin K-dependent factors. For handling, store the vial refrigerated at 4°C in single-use aliquots to preserve activity across repeated freeze-thaw cycles; intended for research use only.