Anti-PRNP Antibody

Polyclonal antibodies raised against the human prion protein PRNP support research into the structural conversion of cellular PrPC into its pathogenic PrPSc isoform. This unconjugated rabbit polyclonal preparation from Antibodies.com is validated for Western blot detection in human samples and for immunohistochemistry on fixed tissue sections, enabling studies of prion-related neurodegeneration, including Creutzfeldt-Jakob disease and other transmissible spongiform encephalopathies. The reagent is supplied as 100 µl of polyclonal antiserum and ships refrigerated to preserve immunoreactivity. Researchers commonly use this antibody to profile PrP expression in brain tissue, to track aggregation-state changes, and to compare normal and disease-associated glycoforms by SDS-PAGE and immunoblotting under reducing conditions.