Anti-PRNP Antibody

Produced by Antibodies.com as a polyclonal reagent raised in rabbit, this unconjugated antibody targets the cellular prion protein encoded by the PRNP gene. The PRNP gene product is a GPI-anchored cell-surface glycoprotein most abundantly expressed in neural tissue, where it plays roles in copper binding, synaptic maintenance, and neuroprotection, while its misfolded isoform (PrP^Sc) is the molecular hallmark of transmissible spongiform encephalopathies such as Creutzfeldt-Jakob disease.

Validated for western blot and immunohistochemistry, the antibody recognizes endogenous PRNP in human, mouse, and rat samples, supporting studies of prion biology, neurodegenerative disease models, and comparative species analysis across cell culture and tissue-based assays. Because the reagent is polyclonal, it offers recognition of multiple epitopes on the prion protein, which can improve reproducibility when probing samples where conformational state or post-translational modification may vary.

Each vial is supplied as 100 µl of unconjugated antiserum in a liquid format. For long-term stability, store at -20 °C in aliquots to limit freeze-thaw cycles; refrigerated short-term storage is appropriate for working solutions. Researchers apply this antibody to western blot detection of PRNP in brain homogenates and transfected cell lines, and to immunohistochemistry on fixed tissue sections, making it a practical tool for basic prion research and translational studies of prion disease pathology.