Anti-PRNP Antibody

Raised in rabbit against the cellular prion protein (PrPC), this unconjugated polyclonal reagent from Antibodies.com detects both full-length PrPC and processed C-terminal fragments of the PRNP gene product on western blot membranes and fixed tissue sections. Cross-reactivity extends to mouse and rat orthologues, supporting comparative work in rodent prion-disease models alongside human samples. Each vial ships as 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol. The host species and unconjugated format pair with anti-rabbit secondary reagents carrying HRP, fluorophore, or biotin reporters. Aliquot upon first thaw to limit freeze-thaw exposure and store at -20°C protected from light; the glycerol cryoprotectant keeps the antibody liquid at -4°C for short-term bench use. Workflows include immunohistochemistry of brain sections from infected and control animals, western blot detection of endogenous PrPC in neural cell lines, and immunoprecipitation of PrP-containing complexes for downstream mass spectrometry.