Anti-PRKG1 Antibody

PRKG1 (cGMP-dependent protein kinase 1, also called PKG-I) is a serine/threonine kinase activated by cyclic GMP that plays central roles in vascular smooth muscle relaxation, platelet aggregation, intestinal peristalsis, and neuronal plasticity.

This rabbit polyclonal primary antibody, supplied by Antibodies.com as a 100 µl vial, was raised against PRKG1 and recognizes the human, mouse, and rat protein. Validated applications include Western blot and immunohistochemistry, supporting detection of endogenous PRKG1 in tissue lysates and fixed sections from cardiovascular, neuronal, and reproductive biology studies.

Researchers use this reagent to investigate cGMP signaling, VASP phosphorylation at Ser239 as a downstream readout, smooth muscle contractility, and PRKG1 expression changes in models of hypertension, erectile dysfunction, and memory formation. The unconjugated format permits pairing with HRP- or fluorophore-labeled secondary antibodies of the user's choice, and the polyclonal nature provides recognition of multiple epitopes across the kinase for robust signal in denaturing and fixed-sample workflows.