Anti-PRKD1 (phospho S738) Antibody

This rabbit polyclonal antibody from Antibodies.com specifically detects PRKD1 phosphorylated at serine 738 (phospho S738), an autophosphorylation site that marks the catalytically active form of protein kinase D1. Raised against a phosphopeptide target, the reagent is supplied as a rabbit IgG preparation in liquid format, unconjugated, and validated for Western blot and immunofluorescence workflows. The antibody recognizes PRKD1 from human, mouse, and rat samples, supporting comparative studies across standard mammalian model systems. Each vial contains 200 µl of antibody, sufficient for multiple immunoblotting or imaging experiments depending on dilution. PRKD1 (also known as PKCµ) operates within signaling cascades that govern NF-κB activation, Golgi trafficking, cell proliferation, and oxidative stress responses, and phosphorylation at S738 serves as a direct biochemical readout of kinase activation downstream of stimuli such as phorbol esters, G-protein-coupled receptors, and oxidative challenge. Researchers working on cardiac hypertrophy, B-cell and T-cell receptor signaling, or GPCR-driven pathways use phospho-S738 antibodies to monitor endogenous PKD1 activity in cell lysates, tissue homogenates, and fixed sections. The polyclonal format offers broader epitope coverage than monoclonal reagents, which can be advantageous when analyzing post-translational modifications that may vary between cell types.