Anti-PRKCE Antibody

Raised in rabbit against PRKCE (Protein Kinase C Epsilon), this polyclonal primary antibody from Antibodies.com is supplied as an unconjugated reagent in a 100 µl vial. The antibody recognizes an epitope within the PRKCE kinase and has been validated for Western blot, immunofluorescence, and immunohistochemistry workflows. It cross-reacts with Human, Mouse, and Rat samples, supporting comparative studies across model organisms and human tissue.

PRKCE is a calcium-independent, diacylglycerol-activated serine/threonine kinase that regulates diverse signaling cascades. Researchers use anti-PRKCE reagents to investigate pathways governing synaptic plasticity, nociception, ischemic preconditioning in cardiomyocytes, and epithelial cell migration. Published work links altered PRKCE activity to glioblastoma invasiveness, diabetic complications affecting vascular smooth muscle, and alcohol-related neuroadaptations, so the reagent is used across oncology, cardiology, neuroscience, and metabolic disease research.

Because the reagent is unconjugated, it can be paired with secondary antibodies matched to many fluorophores or HRP substrates, depending on the application. For immunofluorescence on fixed cells, an Alexa Fluor- or FITC-labeled secondary is commonly selected; for chromogenic IHC on paraffin sections, an HRP polymer system produces a DAB-visible signal. Aliquot upon first use and store frozen to limit freeze-thaw cycles.