Anti-PRKCB Antibody

This polyclonal IgG reagent from Antibodies.com targets protein kinase C beta (PRKCB), a serine/threonine kinase central to phospholipid-dependent signaling cascades downstream of G-protein coupled receptors and tyrosine kinases. Generated in rabbit and supplied as an unconjugated preparation, the antibody is validated for western blot and immunohistochemistry workflows on human and mouse samples. PRKCB controls diverse cellular outputs including B-cell receptor signaling, desensitization of G-protein coupled receptors, regulation of apoptotic pathways, and modulation of the cell cycle, making it a frequent marker in studies of immune cell function, diabetic complications, and certain hematological malignancies.

The product ships as a 100 µl liquid aliquot and should be stored refrigerated; aliquoting and avoidance of repeated freeze-thaw cycles are recommended to preserve antibody activity across long-term use. For western blot, the reagent is applied to lysates derived from cultured mammalian cells or tissue homogenates to reveal the PRKCB band near its expected molecular weight, while immunohistochemistry benefits from antigen retrieval on formalin-fixed paraffin-embedded sections. Researchers investigating kinase signaling pathways, immune cell activation, or glucose transporter trafficking will find this antibody useful for both established protocols and exploratory work, with reactivity confirmed across human and mouse species.