Anti-PRKAR2B Antibody

PRKAR2B encodes the type II beta regulatory subunit of cAMP-dependent protein kinase A, a serine/threonine kinase that mediates many of the cellular effects of cAMP second-messenger signaling. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com was raised against PRKAR2B and is validated for Western blot detection of the endogenous human and mouse protein. The antibody is supplied as 100 µl of liquid in a single vial, suitable for immunoblotting of whole-cell lysates or tissue extracts prepared under standard denaturing SDS-PAGE conditions. As a polyclonal reagent, it recognizes multiple epitopes across the regulatory subunit, which can be useful when probing proteolytic fragments or tissue-specific splice variants of RIIβ. Researchers studying PKA compartmentalization, A-kinase anchoring proteins (AKAPs), and tissue-specific cAMP responses use this reagent in studies of adipose biology, neuronal signaling, and reproductive tissue where RIIβ is highly expressed. Each lot is supplied in a stabilizing buffer for short-term storage at 4 °C and long-term storage at -20 °C, with minimal freeze-thaw cycles recommended to preserve binding activity. Intended for research use only.