Anti-PRKACA Antibody

This unconjugated polyclonal primary antibody from Antibodies.com targets PRKACA, the catalytic α subunit of cAMP-dependent protein kinase A (PKA). Raised in rabbit, the reagent is supplied at 100 µl volume and is validated for Western blot and immunofluorescence workflows with human and mouse samples, supporting studies of cAMP/PKA signaling in metabolic regulation, neuronal function, and steroidogenesis. PRKACA is broadly expressed across tissues and is the focus of research into cortisol-producing adrenal adenomas, ACTH-independent macronodular adrenal hyperplasia, and fibrolamellar hepatocellular carcinoma, where the characteristic DNAJB1-PRKACA fusion transcript has been characterized. The unconjugated format allows flexible pairing with secondary antibodies for fluorescent or chromogenic detection, and the polyclonal profile enables recognition of multiple epitopes on the catalytic subunit. Storage at -20 °C is recommended for long-term stability, with aliquoting advised to minimize repeated freeze-thaw cycles.