Anti-PRKAB2 Antibody

Generated in rabbit against the AMPK β2 regulatory subunit, this unconjugated polyclonal antibody from Antibodies.com recognizes PRKAB2 across human, mouse, and rat samples. Validated for western blot, immunohistochemistry, and immunofluorescence workflows, the reagent is supplied as 100 µl of a 1 mg/ml stock in PBS with 0.1% sodium azide and 50% glycerol. To preserve activity, aliquot the antibody and store at -20 °C, avoiding repeated freeze-thaw cycles.

PRKAB2 forms the carbohydrate-binding regulatory core of the heterotrimeric AMP-activated protein kinase (AMPK) complex, where the β-2 isoform contributes to substrate docking and glycogen sensing. Antibodies raised against this subunit are widely applied in metabolism research, signal transduction studies, and investigations of cellular energy homeostasis under stress conditions such as glucose deprivation, hypoxia, and exercise-mimetic treatments. The polyclonal format offers broader epitope coverage than monoclonal alternatives, supporting consistent detection of full-length PRKAB2 in cell lysates and fixed tissue sections.