Anti-PRIM2 Antibody

Raised in rabbit, this unconjugated polyclonal IgG reagent from Antibodies.com targets the PRIM2 subunit of human DNA primase, the heterodimeric polymerase-alpha complex partner responsible for synthesizing short RNA primers that initiate Okazaki fragment synthesis on the lagging strand. Each vial provides 100 µl of antibody validated for Western blot applications against lysates derived from human cells and tissues, supporting studies of replication-origin firing, S-phase entry, and PRIM2-dependent chromatin loading of PRIM1. The antibody recognizes the full-length PRIM2 polypeptide, enabling researchers to monitor endogenous expression levels in proliferating populations and to probe changes in primase subunit balance associated with oncogenic transformation, since PRIM2 expression is frequently elevated in aggressively dividing tumor cells. Supplied as a liquid polyclonal preparation without a conjugated reporter, the reagent is ready to apply in standard immunoblotting buffer systems and is compatible with HRP- or fluorophore-conjugated secondary antibodies for chemiluminescent or fluorescent detection. Recommended storage at -20 °C in working aliquots preserves activity across multiple freeze-thaw cycles.