Anti-PREPL Antibody

This rabbit polyclonal antibody targets the prolyl endopeptidase-like (PREPL) protein, a serine peptidase implicated in synaptic vesicle exocytosis and regulation of clathrin-mediated endocytosis. Produced by Antibodies.com, the reagent is validated for Western blot and immunohistochemistry workflows and is supplied as a 200 µl aliquot of unconjugated IgG.

The antibody recognizes endogenous PREPL in human, mouse, and rat samples, supporting studies of hypotonia-cystinuria syndrome (HCS) and isolated PREPL deficiency, where loss-of-function variants disrupt neuromuscular signaling. Researchers investigating vesicular trafficking, endocrine secretion, or the broader 2p21 microdeletion phenotype can use this reagent to assess PREPL expression across tissues such as brain, skeletal muscle, and secretory epithelium.

As a polyclonal reagent, the antibody binds multiple epitopes on PREPL, which can improve signal detection in samples where target expression is low. It is shipped as a single-use vial format; aliquoting upon receipt and storage at refrigeration temperatures helps preserve activity across repeated freeze-thaw cycles.