Anti-PRDM14 Antibody

This rabbit polyclonal IgG antibody from Antibodies.com targets PRDM14, a zinc-finger transcription factor encoded by the PRDM14 gene that is essential for primordial germ cell specification and the maintenance of pluripotency in early embryonic cells. Supplied as an unconjugated reagent in a 200 µL vial, the antibody is recommended for western blot (WB) and immunofluorescence (IF) workflows and recognizes the human, mouse, and rat orthologs, making it a practical tool for comparative studies across common mammalian model systems.

PRDM14 normally regulates DNA methylation patterns, histone modifications, and the expression of pluripotency-associated genes such as NANOG and SOX2, and its dysregulation has been implicated in germ cell tumors, breast carcinoma, and lymphoid malignancies, so researchers use Anti-PRDM14 reagents to probe stem cell biology, germline development, and tumor biology. For western blot, the antibody is applied to whole-cell lysates from embryonic stem cells, induced pluripotent stem cells, or relevant tumor lines; for immunofluorescence, it is used on fixed cells or cryosections to localize nuclear PRDM14 expression. The product is a research use only reagent intended for laboratory use.