Anti-PPP3CA Antibody

Calcineurin, encoded by the PPP3CA gene, is a calcium- and calmodulin-dependent serine/threonine phosphatase that mediates NFAT dephosphorylation during T-cell receptor signaling and serves as the intracellular target of the immunosuppressive drugs cyclosporine A and FK506. This Antibodies.com rabbit polyclonal reagent specifically recognizes the catalytic subunit alpha isoform of calcineurin and is supplied as 100 µL of unconjugated serum in a single-use vial format.

Validated for western blot, immunohistochemistry, and immunofluorescence workflows, the antibody cross-reacts with endogenous PPP3CA in human, mouse, and rat samples. Researchers use it to study calcium-dependent signal transduction, cardiac hypertrophy, and neurodevelopmental disorders driven by PPP3CA variants, including experiments tracking calcineurin A expression across tissues, mapping NFAT pathway activation in stimulated lymphocytes, and probing neuronal phosphatase activity in disease models.