Anti-PPP2R2C Antibody

This rabbit polyclonal IgG antibody from Antibodies.com targets PPP2R2C, the B55γ regulatory subunit of serine/threonine protein phosphatase 2A (PP2A). The unconjugated reagent is supplied as 100 µl of polyclonal antiserum raised in rabbit, intended for Western Blot detection of the human PPP2R2C protein in cell and tissue lysate workflows.

PPP2R2C directs PP2A substrate selectivity toward substrates that govern the G1/S transition of the cell cycle and modulates signaling through PI3K/AKT and other pathways, which is why researchers studying mitosis, tumor suppressor regulation, and post-mitotic neuronal signaling use B55γ-specific antibodies to track subunit expression and complex assembly. Immunoblotting with this reagent allows visualization of endogenous PPP2R2C in human samples, supporting studies that compare isoform abundance across cancer cell lines, differentiated neurons, or treated versus untreated conditions.

Recommended use includes standard SDS-PAGE separation followed by transfer to nitrocellulose or PVDF, blocking, and probing at a working concentration appropriate for the target abundance. The polyclonal format provides multi-epitope recognition of the antigen, and the unconjugated IgG isotype enables pairing with HRP- or fluorophore-labeled secondary reagents of the researcher's choice. Storage at refrigerated temperature between uses preserves antibody activity across multiple experiments.