Anti-PPP2CB Antibody

PPP2CB encodes the beta isoform of the catalytic subunit of protein phosphatase 2A (PP2A), one of the most abundant serine/threonine phosphatases in eukaryotic cells and a key regulator of cell cycle progression, apoptosis, and kinase-driven signaling cascades. This polyclonal antibody from Antibodies.com is raised in rabbit and detects the human PPP2CB protein, with cross-reactivity documented in mouse and rat samples. The unconjugated IgG reagent is supplied at 200 µl per vial and is validated for western blot and immunohistochemistry workflows, supporting detection of endogenous PP2A-C beta in cell lysates and fixed tissue sections. For research use only, the antibody should be aliquoted to minimize freeze-thaw cycles of the active fraction. Because the catalytic subunit operates within a heterotrimeric PP2A holoenzyme complex and shares high sequence homology with the alpha isoform (PPP2CA), isoform-selective reagents such as this polyclonal are widely used to resolve subunit-specific contributions to phosphatase activity, substrate selection, and holoenzyme composition in basic and translational research.