Anti-PPP2CB Antibody

Polyclonal antibody raised in rabbit against Protein Phosphatase 2 Catalytic Subunit Beta (PPP2CB), one of two major catalytic isoforms of the serine/threonine phosphatase PP2A. Supplied by Antibodies.com as an unconjugated IgG reagent in a 100 µl vial, this primary antibody is validated for Western blot (WB) and immunohistochemistry (IHC) workflows on human, mouse, and rat samples.

The antibody targets the catalytic core of PP2A, a tumor-suppressive phosphatase complex that controls cell cycle progression, MAPK and Wnt signaling, and pre-mRNA splicing through dephosphorylation of substrates such as Akt, p53, and tau. It is relevant to research on PP2A holoenzyme assembly, dysregulated phosphatase activity in cancer biology, and neuronal phospho-signaling. The polyclonal format enables recognition of multiple epitopes on the beta catalytic subunit, supporting consistent detection in tissue lysates and fixed tissue sections.

Recommended handling: store at -20 °C in working aliquots to preserve activity across repeated freeze-thaw cycles, and protect the original vial from light until first use.