Anti-PPP2CA Antibody

This rabbit polyclonal antibody from Antibodies.com targets PPP2CA, the catalytic alpha subunit of protein phosphatase 2A (PP2A), one of the most abundant serine/threonine phosphatases in eukaryotic cells. PP2A regulates diverse cellular pathways including cell cycle progression, apoptosis, Wnt and MAPK signaling, and PPP2CA dysfunction has been linked to cancer, Alzheimer's disease and cardiac hypertrophy, making this reagent broadly relevant to signal transduction research.

Validated for Western blot and immunofluorescence, the antibody detects endogenous PPP2CA in human, mouse and rat samples. Supplied as 100 µl of unconjugated antiserum raised in rabbit, it is suitable for downstream detection with a labeled secondary antibody of choice. For best results, aliquot upon arrival and store refrigerated; protect from light and limit freeze-thaw cycles to preserve titer. Researchers commonly use it to monitor PP2A catalytic subunit expression and to study PP2A holoenzyme composition across disease models.