Anti-PPP1R1B (phospho T75) Antibody

This polyclonal reagent from Antibodies.com is raised in rabbit and selectively recognizes PPP1R1B phosphorylated at threonine 75, a post-translational modification central to dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) function in striatal medium spiny neurons. Supplied as 100 µL of unconjugated IgG, the antibody is validated for immunofluorescence on human, mouse, and rat tissue sections, supporting studies of dopaminergic pathway activity, reward circuitry, and downstream signal transduction. Researchers investigating Parkinson's disease models, addiction mechanisms, or schizophrenia-related signaling cascades use phospho-T75 DARPP-32 detection to assess regulatory phosphorylation events in the nucleus accumbens and caudate putamen, where altered Thr75 phosphorylation status reflects modulation of upstream kinase activity and dopamine D1 receptor signaling state.