Anti-PPP1R1B Antibody

This polyclonal IgG reagent from Antibodies.com targets PPP1R1B (also known as DARPP-32), a 32 kDa dopamine- and cAMP-regulated phosphoprotein that modulates protein phosphatase 1 (PP1) activity in striatal medium spiny neurons. Raised in rabbit and supplied unconjugated, the antibody supports Western Blot detection of endogenous PPP1R1B in mouse and rat tissue lysates, including striatal samples used in dopaminergic signaling, reward circuitry, and synaptic plasticity studies.

Each vial contains 200 µl of antibody, providing enough volume for multiple blotting experiments. The unconjugated format allows pairing with HRP-, biotin-, or fluorophore-conjugated secondary reagents depending on the detection strategy. For best results, store refrigerated and avoid repeated freeze-thaw cycles; aliquot upon first use to preserve activity. Investigators working on addiction models, Parkinson's disease, and basal ganglia function will rely on this reagent to characterize PPP1R1B phosphorylation states and downstream signaling effects.