Anti-PPP1R1B Antibody

Raised in rabbit as a polyclonal IgG, this unconjugated antibody targets PPP1R1B (also known as DARPP-32), a dopamine- and cAMP-regulated phosphoprotein of approximately 32 kDa that modulates protein phosphatase 1 (PP1) activity in striatal medium spiny neurons. The reagent is supplied by Antibodies.com in a 100 µl vial and has been validated for western blot detection of the mouse and rat orthologs in brain tissue lysates.

PPP1R1B phosphorylation at Thr34 is a widely used molecular readout in neuroscience studies of dopaminergic signaling, reward circuitry, drug addiction, Parkinson's disease models, and antipsychotic pharmacology. The polyclonal format provides broad epitope coverage across the 32 kDa target, supporting clean immunoblot signal in striatal and cortical samples from rodent models. The antibody is intended for research use only and is shipped as a single-use liquid aliquot for downstream immunoblotting workflows.