Anti-PPP1CB Antibody

Raised against the catalytic subunit beta of Protein Phosphatase 1 (PP1), this unconjugated rabbit polyclonal antibody from Antibodies.com supports research into a conserved serine/threonine phosphatase implicated in cell cycle progression, glycogen metabolism, neuronal signaling, and spliceosome assembly. Mutations in PPP1CB have been linked to Noonan-like developmental syndromes, making the reagent relevant to studies of constitutive PP1 hyperactivity in vivo.

Validated applications include Western blot for protein-level expression profiling, immunohistochemistry on formalin-fixed paraffin-embedded tissues for spatial distribution, and immunofluorescence on cultured cells for subcellular localization. The reagent detects endogenous PPP1CB across human, mouse, and rat samples, allowing translational workflows that compare rodent models with patient-derived material.

Supplied as 100 µl of unconjugated antiserum, the antibody pairs with laboratory-defined HRP, biotin, or fluorophore secondary detection systems, letting researchers tailor signal amplification to each application. For handling, aliquot upon first thaw and store at -20°C; avoid repeated freeze-thaw cycles to preserve polyclonal titer. The product is intended for research use only.