Anti-PPP1CA Antibody

Raised in rabbit, this unconjugated polyclonal antibody targets the catalytic subunit alpha isoform of Protein Phosphatase 1 (PPP1CA), a ubiquitously expressed serine/threonine phosphatase that governs cell cycle progression, glycogen metabolism, cytoskeletal dynamics, and synaptic signaling. Antibodies.com supplies the reagent at 1 mg/ml in PBS supplemented with 0.1% sodium azide and 50% glycerol, delivered in a 100 µl vial ready for western blot, immunohistochemistry, and immunofluorescence workflows.

Cross-reactivity with human, mouse, and rat samples makes this reagent practical for comparative studies in cell biology, neuroscience, and metabolic disease research. Polyclonal recognition of multiple epitopes across the conserved phosphatase domain is helpful when probing denatured lysates or fixed tissue where post-translational modifications may mask a single recognition site.

PPP1CA encodes a ~37 kDa catalytic subunit that assembles with dozens of regulatory subunits to form holoenzyme complexes that dephosphorylate glycogen phosphorylase, myosin light chain, and retinoblastoma protein, among other substrates. Store at -20 °C in the supplied glycerol-containing buffer to preserve antibody activity, and aliquot on first use to limit freeze-thaw cycles.