Anti-PPOX Antibody

Targeting protoporphyrinogen oxidase (PPOX), the mitochondrial enzyme that catalyzes the final oxidation step in heme biosynthesis, this rabbit polyclonal reagent from Antibodies.com supports protein-level investigation of PPOX across Human and Mouse samples. The unconjugated antibody format preserves flexibility for downstream labeling and detection chemistries in both Western blot (WB) and immunohistochemistry (IHC) workflows.

Validated applications include Western blot for resolving PPOX from cell lysates and tissue homogenates, and IHC for visualizing subcellular and tissue-level distribution in fixed sections. Cross-reactivity with both Human and Mouse PPOX enables comparative studies between patient-derived material and animal models of variegate porphyria, the autosomal dominant disorder caused by PPOX deficiency.

Each vial contains 100 µl of polyclonal antibody, sufficient for multiple blotting and staining experiments. Routine storage at -20°C in small aliquots minimizes freeze-thaw cycles and preserves reagent performance across extended studies. This reagent is intended for research use only in studies of mitochondrial heme synthesis, porphyria pathogenesis, and related oxidative metabolism research.