Anti-PPM2C Antibody

Raised in rabbit against PPM2C, this polyclonal primary antibody targets a Mg2+-dependent serine/threonine phosphatase that regulates the mitochondrial pyruvate dehydrogenase complex. Antibodies.com supplies the unconjugated reagent at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, packaged as a 100 µl vial ready for standard laboratory aliquoting. The reagent has been validated for Western blot and immunohistochemistry workflows on human, mouse, and rat specimens, supporting comparative metabolic and mitochondrial studies across species. Polyclonal clonality broadens epitope coverage, helping to detect full-length PPM2C as well as its processed mitochondrial isoforms that arise from differential targeting and maturation.

For routine bench use, keep working aliquots refrigerated and protected from light; for long-term storage, freeze at -20°C and limit freeze-thaw cycles to preserve binding activity. The included sodium azide acts as a microbial preservative, which makes the formulation unsuitable for live-cell staining or any in vivo work where azide exposure to animals would be undesirable. Researchers commonly apply this reagent to lysates and fixed tissue sections when investigating phosphatase signaling, pyruvate dehydrogenase regulation, and mitochondrial enzyme biogenesis, and the 50% glycerol cryoprotectant keeps the antibody stable through repeated withdrawal from cold storage.