Anti-PPM1D Antibody

Produced in rabbits and supplied by Antibodies.com as 100 µl of polyclonal serum, this unconjugated reagent targets PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent 1D), a serine/threonine phosphatase also known as WIP1. PPM1D is transcriptionally induced by p53 and acts as a feedback regulator of the DNA damage response, and it is amplified or mutated in breast, ovarian, brain, and gastric cancers as well as in clonal hematopoiesis.

Validated for Western blot and immunohistochemistry workflows on human, mouse, and rat samples, the polyclonal antibody recognizes multiple epitopes across the target, which supports detection of full-length protein and helps laboratories working with truncated variants observed in malignancies. Researchers apply it to track endogenous phosphatase levels in cell lysates and to localize PPM1D expression in formalin-fixed tissue sections, supporting studies of p53 pathway dynamics, oncogenic transformation, and stress signaling.

Each vial is supplied as 100 µl of unconjugated IgG preparation intended for research use only. The reagent is compatible with standard horseradish peroxidase and fluorescence detection chemistries and can be diluted in common blocking buffers for routine blotting and staining protocols.