Anti-PPM1D Antibody

PPM1D, also known as WIP1, is a nuclear serine/threonine phosphatase that plays a central role in the DNA damage response by dephosphorylating key substrates including p53, ATM, CHK1, and CHK2. This rabbit polyclonal antibody from Antibodies.com is raised against PPM1D and validated for western blot detection in human, mouse, and rat samples. Supplied as 200 µl of unconjugated IgG, the reagent integrates into HRP-based chemiluminescent workflows with standard secondary antibodies.

The polyclonal format provides multi-epitope recognition, supporting robust detection of endogenous PPM1D across whole-cell lysates, nuclear extracts, and tumor tissue homogenates. Researchers investigating oncogenic PPM1D amplification in breast and gastric cancers, p53 pathway dynamics following genotoxic stress, and cell-cycle checkpoint regulation rely on this reagent to monitor phosphatase expression in cancer cell lines and primary samples. For optimal stability, store aliquots at -20°C and limit freeze-thaw cycles to preserve antibody titer.