Anti-PPM1A Antibody

PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent 1A) is a member of the PP2C family of serine/threonine phosphatases that governs key signaling cascades, including TGF-β/Smad, MAPK, and stress-activated NF-κB pathways. This unconjugated rabbit polyclonal reagent from Antibodies.com is provided as 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, and has been validated in Western blot, immunohistochemistry, and immunofluorescence workflows using human, mouse, and rat samples.

Investigators rely on this antibody to track endogenous phosphatase expression in studies of cytokine signaling, cellular stress responses, and tumor suppressor biology, where PPM1A-mediated dephosphorylation of substrates such as TAK1, MKK3/6, and Smad2/3 is of mechanistic interest. The polyclonal format broadens epitope coverage and supports reproducible detection in both fixed tissue sections and cultured cell preparations. For best results, aliquot on arrival, store at -20°C, and limit freeze-thaw cycles to preserve binding activity across repeated experiments.