Anti-PPBP Antibody

This rabbit polyclonal antibody from Antibodies.com targets human pro-platelet basic protein (PPBP), a platelet-derived chemokine also referenced as CXCL7, NAP-2, and CTAP-III that drives neutrophil recruitment and megakaryocyte maturation. The unconjugated reagent is supplied as 100 µl of polyclonal antisera raised in rabbit and validated for Western blot and immunohistochemistry on human samples, making it a practical reagent for studies in hematology, vascular biology, and inflammation research.

PPBP is processed from the CXCL7 precursor into several bioactive peptides, and researchers use this reagent to examine endogenous expression in platelets, megakaryocytes, endothelial cells, and tumor microenvironments where the chemokine axis contributes to leukocyte trafficking. Detection of the full-length precursor and its cleavage products by Western blot supports investigations into platelet activation kinetics, while immunohistochemistry on fixed tissue sections enables localization studies in bone marrow, atherosclerotic plaques, and tumor biopsies where PPBP expression is being characterized.

The antibody is provided as a liquid polyclonal preparation without a conjugated reporter, allowing users to pair it with their preferred HRP-, biotin-, or fluorophore-labeled secondary reagents for chromogenic or immunofluorescence workflows. Refrigerated storage preserves polyclonal activity across multiple freeze-thaw cycles when aliquoted on first use, and the rabbit host origin makes it compatible with standard rabbit-on-mouse detection systems for double-labeling experiments.