Anti-POU4F3 Antibody

Raised in rabbit against the POU4F3 transcription factor, this unconjugated polyclonal IgG reagent is supplied by Antibodies.com as 200 µl of liquid and validated for Western Blot detection in human and rat samples. POU4F3, also known as BRN3C, is a POU-homeodomain transcription factor essential for the differentiation, maturation, and survival of inner ear cochlear and vestibular hair cells, and heterozygous loss-of-function mutations in the POU4F3 gene cause autosomal dominant non-syndromic hearing loss DFNA15. Investigators in auditory neuroscience, otology, and hair cell regeneration use anti-POU4F3 antibodies to map developmental expression in the organ of Corti, confirm expression in patient-derived iPSC hair cell models, and probe gene regulatory networks governing sensory cell fate decisions. The polyclonal host format offers broader epitope coverage than monoclonal alternatives, supporting robust recognition of the endogenous protein in Western Blot lysates prepared from cochlear tissue, HEK293 overexpression transfectants, or auditory cell lines such as HEI-OC1. Aliquot upon arrival and store refrigerated to preserve antibody activity across repeated experiments.