Anti-POU2AF1 Antibody

POU2AF1 (also known as OBF-1 or OCA-B) is a B-cell restricted transcriptional coactivator that partners with POU-homeodomain proteins such as Oct-1 and Oct-2 to drive immunoglobulin promoter activity and germinal centre formation. This rabbit polyclonal antibody from Antibodies.com is raised against human POU2AF1 and is supplied as 100 µL of unconjugated antiserum in a vial format suitable for western blot and immunofluorescence workflows on human samples. The polyclonal format increases the chance of recognising multiple epitopes across the protein, which is helpful when probing endogenous expression in B-cell lines, lymphoma-derived cell models, or primary lymphocyte preparations. Because the target is normally expressed in mature B cells and is often dysregulated in diffuse large B-cell lymphoma and other germinal-centre-derived tumours, the reagent is frequently cited in studies of B-cell maturation, class-switch recombination, and transcriptional coactivation of Oct factors. For long-term use, prepare working aliquots upon receipt to limit repeated freeze-thaw cycles, and keep the vial sealed when not in use. The product is intended for research use only.