Anti-PON2 Antibody

For researchers studying the intracellular antioxidant enzyme Paraoxonase 2 (PON2), this rabbit polyclonal antibody from Antibodies.com provides a validated reagent for expression and localization work on human samples. PON2 is a calcium-dependent hydrolase anchored primarily to the inner mitochondrial membrane and the endoplasmic reticulum, where it limits lipid peroxide accumulation and modulates cellular redox signaling. Altered PON2 expression has been documented in atherosclerotic lesions, in pancreatic islets under diabetic stress, in neurodegenerative models, and across several tumor types, supporting studies in cardiovascular, metabolic, neuroscience, and oncology research.

Supplied as 100 µL of unconjugated antiserum, the reagent is validated for Western blot and immunohistochemistry. The polyclonal format allows recognition of multiple epitopes across the 39 kDa PON2 protein, retaining signal when individual epitopes are masked by fixation or denaturation. For best stability, the antibody should be aliquoted to limit freeze-thaw cycles and protected from light when paired with a fluorescent reporter. Typical workflows include probing clarified cell and tissue lysates for expression profiling and staining formalin-fixed paraffin-embedded sections for subcellular and tissue-level localization.