Anti-PON2 Antibody

PON2 (Paraoxonase 2) is a calcium-dependent intracellular lactonase expressed across many human tissues and implicated in cellular antioxidant defense. This unconjugated rabbit polyclonal reagent from Antibodies.com targets the full-length PON2 protein and is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a 100 µl aliquot. The antibody cross-reacts with human, mouse, and rat samples, supporting comparative studies in rodent disease models and human tissue panels.

Validated applications include Western blot for detection of endogenous PON2 in cell lysates and tissue homogenates, as well as immunohistochemistry on fixed sections. Researchers studying oxidative stress, atherosclerosis-related pathways, HDL function, and metabolic disorders have used PON2 immunoblotting to track expression changes under different experimental conditions. The polyclonal format provides recognition of multiple epitopes, which can be helpful when working with truncated or post-translationally modified forms.

Storage recommendations call for short-term handling at 4 °C with longer-term storage at -20 °C, and the glycerol-containing buffer protects the protein against repeated freeze-thaw cycles. Sodium azide is included to prevent microbial contamination. The unconjugated format allows users to pair the antibody with their preferred reporter or label of choice, supporting flexibility in custom assay development for research use only.