Anti-PON1 Antibody

This polyclonal antibody targets Paraoxonase 1 (PON1), a calcium-dependent arylesterase that circulates on high-density lipoprotein particles and contributes to organophosphate detoxification and protection against lipid peroxidation. Distributed by Antibodies.com as 100 µl of unconjugated rabbit antiserum, the reagent is validated for Western blot and immunohistochemistry workflows on human and mouse tissue and lysate samples.

Raised in rabbit host animals, the polyclonal antibody provides broad epitope coverage of PON1, a protein widely investigated in cardiovascular research, atherosclerosis models, and toxicology studies of environmental organophosphate exposure. The unconjugated format gives end users flexibility to pair the reagent with their preferred secondary detection chemistry, supporting fluorescence, chromogenic, or chemiluminescent readouts. Confirmed reactivity with both human and mouse PON1 enables comparative work across species, including transgenic and knockout disease models.

Typical applications include probing hepatocyte lysates, liver cryosections, and serum-derived HDL fractions to track PON1 abundance and responses to drug or environmental challenges. Combined Western blot and immunohistochemistry validation makes the reagent appropriate for correlating PON1 levels across tissue panels in translational cardiovascular and metabolic disease programs.