Anti-POMT1 Antibody

This polyclonal antibody from Antibodies.com targets POMT1 (Protein O-Mannosyltransferase 1), a type II transmembrane enzyme localized to the endoplasmic reticulum that initiates the first mannosylation step in O-mannosyl glycan biosynthesis on alpha-dystroglycan. Because loss-of-function mutations in POMT1 underlie dystroglycanopathies such as Walker-Warburg syndrome and other congenital muscular dystrophies, reliable detection of the endogenous protein supports studies of glycosylation, muscle development, and neuronal migration.

Supplied as 100 µl of unconjugated rabbit antiserum, the reagent is validated for Western blot and immunohistochemistry on human samples, enabling visualization of the approximately 85 kDa POMT1 polypeptide in tissue sections and cell lysates. For handling, store aliquots at -20 °C and avoid repeated freeze-thaw cycles to preserve antibody activity across multiple experiments.

Researchers working on dystroglycanopathy mechanisms, congenital muscular dystrophy models, and O-glycan biosynthesis pathways use this reagent to map POMT1 expression patterns, confirm variant effects, and characterize the molecular basis of glycosylation defects in disease.