Anti-POMC Antibody

Pro-opiomelanocortin (POMC) is a precursor polypeptide that undergoes tissue-specific post-translational cleavage to yield several bioactive hormones, including adrenocorticotropic hormone (ACTH), α-, β-, and γ-melanocyte-stimulating hormones, and β-endorphin. This unconjugated rabbit polyclonal antibody from Antibodies.com targets POMC and is validated for Western blotting and immunohistochemistry on human, mouse, and rat samples, supporting studies of pituitary corticotrophs, hypothalamic arcuate nucleus neurons, and other neuroendocrine tissues where the precursor is expressed. Researchers investigating the hypothalamic-pituitary-adrenal (HPA) axis, melanocortin signaling in energy homeostasis, appetite regulation, stress response, or ACTH-related disorders such as Cushing syndrome and adrenal insufficiency can use the reagent to track precursor expression alongside its processed peptides. The product is supplied as a 100 µl aliquot of polyclonal serum suitable for chromogenic IHC on formalin-fixed sections and immunoblotting of cell or tissue lysates, and the unconjugated format gives laboratories flexibility to pair it with their preferred secondary detection systems.