Anti-Poly (A)-specific ribonuclease PARN Antibody

This rabbit polyclonal reagent from Antibodies.com specifically recognizes Poly(A)-specific ribonuclease PARN, a 3'-exoribonuclease that catalyzes deadenylation of messenger RNA poly(A) tails. The unconjugated antibody is supplied as 100 µg in a single vial and is validated for Western Blot and Immunohistochemistry workflows on human-derived samples, supporting detection of endogenous PARN in cell lysates and formalin-fixed tissue sections.

PARN participates in post-transcriptional gene regulation, including mRNA stability control, translation efficiency, nonsense-mediated decay, telomere maintenance, and the DNA damage response, and PARN dysfunction has been associated with dyskeratosis congenita and idiopathic pulmonary fibrosis. The polyclonal format enables recognition of multiple epitopes on the approximately 73 kDa target protein. Store refrigerated; aliquot to minimize freeze-thaw cycles and preserve reactivity across repeated experiments.