Anti-POLR3A Antibody

Rabbit polyclonal antibody targeting POLR3A, the catalytic subunit of RNA polymerase III, supplied by Antibodies.com in a 100 µL vial format. POLR3A encodes the largest subunit of RNA polymerase III, the enzyme complex responsible for transcribing small structural RNAs including tRNAs, 5S rRNA, U6 snRNA, and 7SL RNA. This unconjugated polyclonal reagent is validated for Western blot (WB) and immunofluorescence (IF) applications on human samples, raised in a rabbit host. The antibody supports research into POLR3-related hypomyelinating leukodystrophies, including 4H syndrome (hypomyelination, hypodontia, and hypogonadotropic hypogonadism) and Wiedemann-Rautenstrauch syndrome, as well as broader studies of RNA polymerase III transcription machinery and small RNA biogenesis. Researchers investigating nuclear localization patterns or POLR3A expression dynamics can apply this reagent in cell-based imaging workflows. Aliquot upon receipt and store refrigerated to preserve activity through repeated freeze-thaw cycles. For research use only.