Anti-POLR2L Antibody

Raised in rabbit against the POLR2L subunit of RNA polymerase II, this unconjugated polyclonal antibody from Antibodies.com is supplied as 100 µl of ready-to-use reagent. POLR2L, also called RPB10, is a shared small subunit of RNA polymerases I, II, and III that sits at the catalytic core, helping stabilize the enzyme complex during transcription of protein-coding genes and certain non-coding RNAs.

The reagent is validated for Western blot and immunofluorescence workflows, and it cross-reacts with Human, Mouse, and Rat samples, making it a practical choice for comparative studies across standard mammalian model systems and human cell lines. Because the target is a conserved subunit of the basal transcription machinery, this antibody suits research that probes general transcriptional output, Pol II subunit stoichiometry, Pol II assembly, and the response of RNA polymerase to cellular stress or small-molecule inhibitors.

As an unconjugated polyclonal, the antibody can be paired with many secondary labels of the researcher's choice, supporting flexibility in chromogenic and fluorescence-based detection. Storage temperature and handling details should be confirmed on the accompanying datasheet prior to first use.