Anti-POLG2 Antibody

This rabbit polyclonal reagent from Antibodies.com targets POLG2, the accessory subunit of mitochondrial DNA polymerase gamma that supports processive mtDNA replication and repair. The antibody is supplied at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.3, in a 100 µl vial. It is validated for Western blot and recognizes endogenous POLG2 in human, mouse, and rat lysates.

Researchers apply this antibody to investigations of mtDNA maintenance, mitochondrial biogenesis, and disorders linked to POLG2 dysfunction, including autosomal dominant progressive external ophthalmoplegia and mtDNA depletion phenotypes. For best stability, store the vial at -20 °C and avoid repeated freeze-thaw cycles; the azide preservative permits short-term handling on wet ice for working dilutions. This unconjugated format pairs readily with HRP, fluorescent, or biotin-labeled secondary reagents depending on the downstream detection chemistry chosen for the immunoblot.