Anti-POLE3 Antibody

POLE3 (DNA Polymerase Epsilon Subunit 3), also referred to as p17 or CHRAC-17, is a chromatin-binding component of the DNA polymerase epsilon complex that participates in leading-strand DNA synthesis, chromatin remodeling, and the cellular response to DNA damage. The unconjugated rabbit polyclonal reagent distributed by Antibodies.com is raised against this subunit and is validated for Western blot (WB) detection of the endogenous human protein and for immunohistochemistry (IHC) localization in fixed tissue sections. Provided as a 100 µL liquid aliquot, the antibody enables researchers investigating S-phase replication fidelity, histone chaperone function, and polymerase epsilon-associated repair pathways to probe POLE3 expression in cell lysates and tissue specimens. The polyclonal format increases the likelihood of recognizing multiple epitopes on the small 17 kDa subunit, which is useful when examining cleavage products or post-translationally modified forms. The unconjugated preparation allows downstream pairing with user-selected reporter-conjugated secondary antibodies for flexible detection chemistries across blot, slide, and immunoprecipitation workflows, supporting research-use-only applications in basic cell biology and genome stability studies.