Anti-POLE3 Antibody

Polyclonal rabbit antibody targeting POLE3 (DNA Polymerase Epsilon subunit 3), the chromatin-accessory subunit that supports leading-strand DNA synthesis and couples polymerase epsilon activity to chromatin remodeling during S phase. This unconjugated primary reagent from Antibodies.com is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, packaged as a 100 µl volume sufficient for multiple immunodetection experiments.

Validated for western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF), the antibody detects endogenous POLE3 in human, mouse, and rat tissue or cell samples, supporting comparative work in DNA replication biology, chromatin assembly research, and tumor biology where polymerase epsilon accessory subunit expression is being characterized. The glycerol-containing buffer permits storage at -20 °C; aliquoting on first use is advised to limit freeze-thaw cycles, and the sodium azide preservative should be handled with appropriate ventilation.