Anti-POLE3 Antibody

Raised in rabbit and supplied by Antibodies.com as 200 µl of unconjugated polyclonal IgG, this reagent specifically targets POLE3, the smallest accessory subunit of human DNA polymerase epsilon. POLE3, also known as CHRAC-17 for its role within the CHromatin Accessibility Complex, is a histone-fold protein that partners with the catalytic POLE subunit to support leading-strand DNA synthesis, nucleosome assembly, and chromatin remodeling during S phase.

This polyclonal antibody is validated for western blot (WB) and immunofluorescence (IF) applications and has been confirmed to react with human and mouse samples. The unconjugated format allows users to couple the antibody to their preferred fluorophore or enzyme for downstream detection in cell biology and DNA replication studies, including immunostaining of nuclear POLE3 localization and probing of polymerase epsilon accessory complex composition on western blots.