Anti-POLB Antibody

Produced by Antibodies.com as an unconjugated rabbit polyclonal reagent, this preparation binds POLB (DNA polymerase beta), the short-patch base excision repair polymerase responsible for filling single-nucleotide gaps in damaged DNA and sustaining genome stability across mammalian tissues. The polyclonal response covers several epitopes on the human target, enabling detection in denatured lysate preparations as well as fixed tissue sections.

Applied to western blot analysis of cell and tissue lysates, immunohistochemistry on formalin-fixed paraffin-embedded sections, and immunofluorescence imaging of cultured cells, the reagent supports antibody-based localization studies across three complementary readouts. Cross-reactivity with human, mouse, and rat orthologs allows comparative work between clinical specimens and rodent models routinely used in DNA repair and genotoxicity research.

Shipped as a 100 µl liquid aliquot in a single vial, the antibody is intended for dilution into standard immunodetection buffers; refrigerated storage protected from light preserves activity through freeze-thaw cycles of working aliquots prepared from the supplied vial.