Anti-POC1B Antibody

Raised in rabbit against POC1B, this unconjugated polyclonal IgG reagent from Antibodies.com is supplied as 100 µl of antiserum for Western blot detection of endogenous protein in lysates from human, mouse, and rat samples. The target, POC1B, encodes a centriolar protein required for centriole duplication and primary cilium assembly, and loss-of-function mutations in this gene have been implicated in autosomal recessive retinal ciliopathies, including retinitis pigmentosa and cone-rod dystrophy. Investigators working on centrosome biogenesis, ciliary signaling pathways, or retinal degeneration models apply the antibody to compare expression across cultured cell lines and developing tissues, pairing the unconjugated primary with HRP, alkaline phosphatase, or fluorophore-labelled secondary reagents matched to their membrane-based detection chemistry. Store refrigerated upon arrival and aliquot the working stock to minimize repeated freeze-thaw cycles on long-term Western blot campaigns that track this centriolar protein through differentiation or disease-model time courses.